Gene information
Official symbol F11
Official full name coagulation factor XI
Gene type protein-coding gene
Chromosome4q35.2
Alias symbolFXI
Resources
Entrez Gene 2160
HGNC HGNC:3529
Ensembl ENSG00000088926
Vega OTTHUMG00000150311
UCSC uc003iza.2
GO terms: 31 records
GO Description Category LogP Number of genes Detail
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0008238 exopeptidase activity GO Molecular Functions -3.53660715 7 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0016485 protein processing GO Biological Processes -23.0561441 30 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0030193 regulation of blood coagulation GO Biological Processes -37.6853179 30 More
GO:0030195 negative regulation of blood coagulation GO Biological Processes -29.1940441 22 More
GO:0031638 zymogen activation GO Biological Processes -13.0866363 13 More
GO:0031639 plasminogen activation GO Biological Processes -7.61185031 7 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050818 regulation of coagulation GO Biological Processes -40.0839917 32 More
GO:0050819 negative regulation of coagulation GO Biological Processes -31.8350192 24 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051604 protein maturation GO Biological Processes -20.0856790 31 More
GO:0051917 regulation of fibrinolysis GO Biological Processes -20.6622986 13 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0061045 negative regulation of wound healing GO Biological Processes -28.2986689 25 More
GO:1900046 regulation of hemostasis GO Biological Processes -39.0044157 31 More
GO:1900047 negative regulation of hemostasis GO Biological Processes -30.8008788 23 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903035 negative regulation of response to wounding GO Biological Processes -27.3379640 26 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
Drug-Gene interaction
view
Related drugs: 2 records
Drug name Interaction type Source PMID View
sulfated pentagalloylglucoside DTC 23316863 view
thrombin activator NCI 978716617635715 view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
coagulation factor XI proteomics acute myocardial infarction[diagnosis] acute myocardial infarction La Follette L et al. J Lab Clin Med. 1987
coagulation factor XI proteomics adverse events[prognosis (bad)] acute myocardial infarction Loeffen R et al. Thromb Res. 2014
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